Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642823 | 0.84 | CES2 (0.56) | CES2NPSR1P2RX1LMNASRD5A2 | |
| SCHEMBL4396979 | 0.82 | CES2 (0.55) | CES2NPSR1P2RX1LMNASRD5A2 | |
| Hydrochloric Acid SCHEMBL4400848 | 0.81 | CES2 (0.53) | CES2NPSR1P2RX1LMNASRD5A2 | |
| SCHEMBL3555007 | 0.79 | CES2 (0.60) | CES2NPSR1P2RX1LMNASRD5A2 | |
| SCHEMBL11553879 | 0.79 | CES2 (0.51) | CES2NPSR1P2RX1LMNASRD5A2 | |
| SCHEMBL10436303 | 0.79 | CES2 (0.65) | CES2NPSR1P2RX1LMNAHTT | |
| SCHEMBL10285693 | 0.77 | CES2 (0.48) | CES2SRD5A2TLR7PTGS1 | |
| SCHEMBL15630195 | 0.77 | CES2 (0.62) | CES2NPSR1P2RX1LMNASRD5A2 | |
| SCHEMBL524006 | 0.76 | CES2 (0.60) | CES2SRD5A2PTGS1 | |
| SCHEMBL1826394 | 0.75 | NPSR1 (0.55) | CES2NPSR1P2RX1LMNASRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009068652-A1 | 2, 6-DISUBSTITUTED PYRIDINES AND 2, 4-DISUBSTITUTED PYRIMIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |