SCHEMBL3555007

SCHEMBL3555007

N=C(Cl)c1cccc(C(F)(F)F)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.60
SRD5A2 P31213 1/20 0.50
CNR1 P21554 1/20 0.48
LMNA P02545 2/20 0.47
NPSR1 Q6W5P4 1/20 0.47
P2RX1 P51575 1/20 0.47
POLB P06746 2/20 0.46
HPGD P15428 1/20 0.46
KCNQ3 O43525 1/20 0.46
KCNQ2 O43526 1/20 0.46
KCNE1 P15382 1/20 0.46
KCNQ1 P51787 1/20 0.46
MGLL Q99685 1/20 0.46
HTT P42858 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45
ALDH1A1 P00352 2/20 0.45
MAOB P27338 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15630195 0.82 CES2 (0.62) CES2SRD5A2LMNANPSR1P2RX1
SCHEMBL29425720 0.80 CES2 (0.71) CES2SRD5A2CNR1LMNANPSR1
SCHEMBL13064615 0.80 CES2 (0.60) CES2SRD5A2LMNANPSR1P2RX1
SCHEMBL524006 0.80 CES2 (0.60) CES2SRD5A2TSHRMAPK1
SCHEMBL1449175 0.80 CES2 (0.60) CES2SRD5A2LMNANPSR1P2RX1
SCHEMBL19310 0.80 CES2 (0.71) CES2SRD5A2CNR1LMNANPSR1
SCHEMBL8048477 0.79 CES2 (0.55) CES2SRD5A2CNR1LMNANPSR1
SCHEMBL4086253 0.79 CES2 (0.69) CES2SRD5A2LMNANPSR1P2RX1
Hydrochloric Acid SCHEMBL1085054 0.78 CES2 (0.58) CES2SRD5A2TSHRMAPK1KMT2A
SCHEMBL350153 0.78 CES2 (0.74) CES2SRD5A2LMNANPSR1P2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745465-B2 Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof CYTRX CORPORATION (US) 2010-06-29 US disclosed