Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.41 |
| ▸ | RELA | Q04206 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042861 | 0.94 | HCAR3 (0.48) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8050451 | 0.92 | MAPT (0.47) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8050220 | 0.87 | MAPT (0.43) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL8050295 | 0.87 | ALDH1A1 (0.39) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8044141 | 0.87 | ALDH1A1 (0.48) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8043375 | 0.86 | SMN1; SMN2 (0.45) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8043268 | 0.85 | ALDH1A1 (0.38) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8052166 | 0.84 | ALDH1A1 (0.58) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8042101 | 0.82 | HPGD (0.45) | HCAR3ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8050866 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |