Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048558 | 0.94 | HCAR3 (0.46) | HCAR3ALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL8050451 | 0.90 | MAPT (0.47) | HCAR3ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL8050295 | 0.89 | ALDH1A1 (0.39) | HCAR3ALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL8043268 | 0.87 | ALDH1A1 (0.38) | HCAR3ALDH1A1MAPTLMNAUSP2 | |
| SCHEMBL8050220 | 0.85 | MAPT (0.43) | ALDH1A1MAPTLMNAHPGDPOLB | |
| SCHEMBL8044141 | 0.85 | ALDH1A1 (0.48) | HCAR3ALDH1A1MAPTLMNATSHR | |
| SCHEMBL8043375 | 0.84 | SMN1; SMN2 (0.45) | HCAR3ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL8052166 | 0.83 | ALDH1A1 (0.58) | HCAR3ALDH1A1MAPTLMNATSHR | |
| SCHEMBL8051850 | 0.82 | PKM (0.41) | ALDH1A1MAPTLMNAUSP2TSHR | |
| SCHEMBL8047359 | 0.81 | PDK1 (0.52) | ALDH1A1MAPTLMNATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |