Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.74 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048954 | 1.00 | TRPA1 (0.74) | TRPA1TRPM8NPC1KDM4EGAA | |
| SCHEMBL8065854 | 0.91 | TRPA1 (0.74) | TRPA1TRPM8NPC1KDM4EL3MBTL1 | |
| SCHEMBL8065856 | 0.91 | TRPA1 (0.74) | TRPA1TRPM8NPC1KDM4EL3MBTL1 | |
| SCHEMBL2779436 | 0.86 | TRPA1 (0.74) | TRPA1TRPM8NPC1KDM4EGAA | |
| SCHEMBL2779439 | 0.86 | TRPA1 (0.74) | TRPA1TRPM8NPC1KDM4EGAA | |
| SCHEMBL8060572 | 0.86 | TRPA1 (1.00) | TRPA1TRPM8NPC1KDM4EL3MBTL1 | |
| SCHEMBL8060574 | 0.86 | TRPA1 (1.00) | TRPA1TRPM8NPC1KDM4EL3MBTL1 | |
| SCHEMBL8065329 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8KDM4EL3MBTL1MAPT | |
| SCHEMBL8065330 | 0.85 | TRPA1 (0.58) | TRPA1TRPM8KDM4EL3MBTL1MAPT | |
| SCHEMBL8060511 | 0.84 | TRPA1 (0.76) | TRPA1TRPM8NPC1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |