SCHEMBL8065856

SCHEMBL8065856

COc1ccccc1C=CC(=O)Nc1cc(Cl)ccc1C(=O)O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 3/20 0.74
TRPM8 Q7Z2W7 2/20 0.74
GRIK1 P39086 2/20 0.64
NPC1 O15118 4/20 0.59
L3MBTL1 Q9Y468 2/20 0.59
MAPT P10636 5/20 0.58
MEN1 O00255 6/20 0.57
KMT2A Q03164 6/20 0.57
HPGD P15428 5/20 0.57
ALDH1A1 P00352 5/20 0.57
POLB P06746 1/20 0.57
GLA P06280 1/20 0.56
CYP3A4 P08684 3/20 0.55
TP53 P04637 2/20 0.55
HIF1A Q16665 2/20 0.55
CYP1A2 P05177 2/20 0.55
CYP2C9 P11712 2/20 0.55
CYP2C19 P33261 2/20 0.55
PKM P14618 2/20 0.55
NFKB1 P19838 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8065854 1.00 TRPA1 (0.74) TRPA1TRPM8GRIK1NPC1L3MBTL1
SCHEMBL8048954 0.91 TRPA1 (0.74) TRPA1TRPM8GRIK1NPC1L3MBTL1
SCHEMBL8048948 0.91 TRPA1 (0.74) TRPA1TRPM8GRIK1NPC1L3MBTL1
SCHEMBL2779439 0.89 TRPA1 (0.74) TRPA1TRPM8GRIK1NPC1L3MBTL1
SCHEMBL2779436 0.89 TRPA1 (0.74) TRPA1TRPM8GRIK1NPC1L3MBTL1
SCHEMBL27696876 0.86 TRPA1 (0.74) TRPA1TRPM8NPC1L3MBTL1MAPT
SCHEMBL8060572 0.86 TRPA1 (1.00) TRPA1TRPM8NPC1L3MBTL1MAPT
SCHEMBL8060574 0.86 TRPA1 (1.00) TRPA1TRPM8NPC1L3MBTL1MAPT
SCHEMBL27696801 0.85 TRPA1 (0.73) TRPA1TRPM8NPC1L3MBTL1MAPT
SCHEMBL8063189 0.85 ALDH1A1 (0.61) TRPA1TRPM8GRIK1L3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed