Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043654 | 0.84 | TSHR (0.52) | HDAC6TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8032654 | 0.83 | RPA1 (0.51) | RPA1HDAC6TSHRIKBKBHSD17B10 | |
| SCHEMBL8042860 | 0.82 | HDAC6 (0.44) | HDAC6HDAC2HDAC1MEN1HTT | |
| SCHEMBL8049440 | 0.80 | RPA1 (0.51) | RPA1TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8032459 | 0.80 | HSD17B10 (0.49) | HDAC6TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8043803 | 0.79 | HDAC6 (0.41) | HDAC6HDAC2HDAC1TSHRHSD17B10 | |
| SCHEMBL8042913 | 0.79 | ALDH1A1 (0.44) | HDAC6HDAC2HDAC1TSHRKDM4E | |
| SCHEMBL8045038 | 0.79 | TSHR (0.47) | HDAC6TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8046929 | 0.78 | TSHR (0.52) | HDAC6TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8044722 | 0.78 | RPA1 (0.45) | RPA1TSHRHSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |