Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | NR1D2 | Q14995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988981 | 0.90 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10078307 | 0.86 | OPRD1 (0.47) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL23232242 | 0.82 | OPRM1 (0.59) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL8044669 | 0.81 | OPRL1 (0.56) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10057664 | 0.81 | OPRM1 (0.68) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10994724 | 0.80 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL6926820 | 0.80 | OPRD1 (0.44) | OPRM1OPRD1OPRK1OPRL1HDAC4 | |
| SCHEMBL17888234 | 0.80 | OPRM1 (0.62) | OPRM1OPRD1OPRK1OPRL1MAPK1 | |
| SCHEMBL16838121 | 0.79 | MAPK1 (0.43) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL10990189 | 0.79 | MAPK1 (0.40) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317134-A1 | UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF | RAPT THERAPEUTICS INC (US) | 2021-10-14 | — | — | US | disclosed |
| US-10196376-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170334882-A1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS, INC | 2017-11-23 | — | — | US | disclosed |
| US-9751857-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| EP-2220083-B1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2017-07-19 | — | — | EP | disclosed |
| US-9676747-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2017-06-13 | — | — | US | disclosed |
| US-9061008-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061008-B2 | Hepatitis B antiviral agents | NOVIRA THERAPEUTICS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-8785486-B2 | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2014-07-22 | — | — | US | disclosed |
| US-8785486-B2 | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors | Janssen Pharmaceuticals, Inc. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20110009441-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| US-20100144701-A1 | Modulators of CB1 Receptors | 7TM PHARMA A/S (DK) | 2010-06-10 | — | — | US | disclosed |
| WO-2009062676-A2 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |
| US-4954511-A | ALLEVIATING PAIN, TREATING DEPRESSION, CONVULSIONS AND HYPERTENSION | HOECHST-ROUSSELL PHARMACEUTICALS INC. (US) | 1990-09-04 | — | — | US | disclosed |
| US-4914204-A | ANALGESICS, ANTIDEPRESSANTS, ANTICONVULSANTS, HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-04-03 | — | — | US | disclosed |
| EP-0333027-A1 | 4-Pentafluorophenoxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4524207-A | Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| US-4409229-A | Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-10-11 | — | — | US | disclosed |
| EP-0002283-B1 | SUBSTITUTED 1,3-DIHYDROSPIRO (BENZO(C)THIOPHENES), PROCESS FOR THEIR PREPARATION AND THESE COMPOUNDS FOR USE AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-08-24 | — | — | EP | disclosed |
| EP-0002283-A1 | Substituted 1,3-dihydrospiro (benzo(c)thiophenes), process for their preparation and these compounds for use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10196376-B2 | Hepatitis B antiviral agents | HAVCR2, EIF2AK2, IRF3 | OPRM1 3702/4885OPRD1 3394/4885OPRK1 2596/4885 |
| US-20110009441-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM1, GRIA2 | OPRM1 257/4885OPRD1 138/4885OPRK1 352/4885 |
| US-20100144701-A1 | Modulators of CB1 Receptors | CNR1, CNR2, GPR6 | OPRM1 81/4885OPRD1 78/4885OPRK1 98/4885 |
| US-20210317134-A1 | UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF | USP7, SENP7, USP8 | OPRM1 4147/4885OPRD1 3897/4885OPRK1 3916/4885 |
| US-20170334882-A1 | HEPATITIS B ANTIVIRAL AGENTS | HAVCR2, EIF2AK2, IRF3 | OPRM1 3702/4885OPRD1 3394/4885OPRK1 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.