Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043531 | 0.85 | METAP1 (0.49) | OPRK1GRM5HTTMAPTHIF1A | |
| SCHEMBL8032107 | 0.82 | HIF1A (0.45) | GRM5HTTHIF1AKDM4ESMN1; SMN2 | |
| SCHEMBL8043507 | 0.82 | NPC1 (0.43) | GRM5ALDH1A1HTTMAPTHIF1A | |
| SCHEMBL8042356 | 0.81 | HIF1A (0.50) | OPRK1GRM5ALDH1A1HTTMAPT | |
| SCHEMBL8041617 | 0.81 | MAPT (0.47) | OPRK1GRM5HTTMAPTHIF1A | |
| SCHEMBL8041606 | 0.81 | HIF1A (0.51) | GRM5HTTMAPTHIF1AKDM4E | |
| SCHEMBL8045505 | 0.81 | HIF1A (0.45) | GRM5HTTHIF1AKDM4ESMN1; SMN2 | |
| SCHEMBL8043609 | 0.80 | HIF1A (0.47) | GRM5ALDH1A1HTTMAPTHIF1A | |
| SCHEMBL8032085 | 0.79 | HIF1A (0.52) | OPRK1ALDH1A1HTTMAPTHIF1A | |
| SCHEMBL8043558 | 0.79 | TRPV1 (0.46) | GRM5ALDH1A1HTTHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |