Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043531 | 0.86 | METAP1 (0.49) | NPC1RAB9ASMN1; SMN2GRM5HTT | |
| SCHEMBL8032107 | 0.84 | HIF1A (0.45) | SMN1; SMN2GRM5HTTHIF1AKDM4E | |
| SCHEMBL8042356 | 0.83 | HIF1A (0.50) | RAB9ASMN1; SMN2L3MBTL1ALDH1A1GRM5 | |
| SCHEMBL8041617 | 0.83 | MAPT (0.47) | NPC1RAB9ASMN1; SMN2L3MBTL1GRM5 | |
| SCHEMBL8045505 | 0.82 | HIF1A (0.45) | SMN1; SMN2GRM5HTTHIF1AKDM4E | |
| SCHEMBL8041606 | 0.82 | HIF1A (0.51) | SMN1; SMN2GRM5HTTHIF1AMAPT | |
| SCHEMBL8049571 | 0.82 | OPRK1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL8043609 | 0.81 | HIF1A (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1GRM5 | |
| SCHEMBL8032085 | 0.81 | HIF1A (0.52) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL8043558 | 0.80 | TRPV1 (0.46) | RAB9ASMN1; SMN2ALDH1A1GRM5HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |