Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27577950 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3BLM | |
| Maleic Acid SCHEMBL6830928 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL4770513 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL4770527 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL15689651 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL365675 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM | |
| Maleic Acid SCHEMBL15239556 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL5874229 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL1062045 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM | |
| Fumaric Acid SCHEMBL365677 | 0.85 | TSHR (0.75) | TSHRTP53EGLN1EGLN3BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1726208-A | Complexes of E-2-methoxy-N-(3-{4- [3-methyl-4-(6-methyl- pyridin -3-yloxy)-phenylamino] -quinazolin-6-yl}-allyl)-acetamide, their method of production, and use | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | claimed |
| CN-102234287-B | Nitro glyoxaline compound, Preparation Method And The Use | SHANGHAI SUN-SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO., LTD. (CN) | 2015-08-05 | — | — | CN | disclosed |
| CN-103396399-B | Nitrogenated aromatic 6-membered ring derivative, and pharmaceutical agent comprising same | DAIICHI SANKYO CO LTD | 2015-04-29 | — | — | CN | disclosed |
| CN-102307869-A | Aminopyrazine derivative and medicine | NIPPON SHINYAKU CO LTD | 2012-01-04 | — | — | CN | disclosed |
| CN-101781293-A | Antibacterial compound, preparation method and application thereof | BENXI RUISHENG PHARMACEUTICAL | 2010-07-21 | — | — | CN | disclosed |
| CN-101472892-A | Organic compounds | NOVARTIS AG (CH) | 2009-07-01 | — | — | CN | disclosed |
| CN-101437811-A | Quinoline derivatives | ASTRAZENECA AB (SE) | 2009-05-20 | — | — | CN | disclosed |
| US-6127447-A | RADIATION CURABLE COATING COMPOSITION INCLUDES AN EFFECTIVE AMOUNT OF CATIONIC PHOTOINITIATOR IN COMBINATION WITH A CHARGE TRANSFER COMPLEX | FUSION UV SYSTEMS, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0883652-B1 | RADIATION CURABLE COATING COMPOSITION | DSM NV (NL) | 2000-03-15 | — | — | EP | disclosed |
| US-6025409-A | COMPRISING (A) UNSATURATED COMPOUND HAVING AT LEAST ONE MALEATE, FUMERATE, ITACONATE, CITRACONATE OR MESACONATE GROUP; (B) AN UNSATURATED VINYLETHER COMPOUND AND A COMPOUND WHICH FORMS A STRONG EXCIPLEX WITH (A) OR (B); | DSM N.V. (NL) | 2000-02-15 | — | — | US | disclosed |
| EP-0883652-A1 | RADIATION CURABLE COATING COMPOSITION | DSM N.V. (NL) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997031981-A1 | RADIATION CURABLE COATING COMPOSITION | DSM N.V. (NL) | 1997-09-04 | — | — | WO | disclosed |
| CN-1069490-A | Urea derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1993-03-03 | — | — | CN | disclosed |