Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.75 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.75 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.53 |
| ▸ | GABRP | O00591 | 2/20 | 0.50 |
| ▸ | GABRD | O14764 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.50 |
| ▸ | GABRE | P78334 | 2/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5874224 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL5076417 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL5318712 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL1062042 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL1062045 | 1.00 | TSHR (0.75) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2223143 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL1924596 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL9261130 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL554796 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL11284804 | 0.87 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | claimed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | claimed |
| CN-115385845-B | Preparation of pyrrole sulfonic acid compound salt | 江苏柯菲平医药股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-115385845-A | Preparation of pyrrole sulfonic acid compound salt | 江苏柯菲平医药股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115322100-A | Delta, epsilon-alkenyl ketone compound and preparation method and application thereof | 南京工业大学 | 2022-11-11 | — | — | CN | disclosed |
| CN-107814758-B | Preparation of pyrrole sulfonic acid compound salt | 江苏柯菲平医药股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| CN-107814758-B | Preparation of pyrrole sulfonic acid compound salt | 江苏柯菲平医药股份有限公司 | 2022-10-11 | — | — | CN | disclosed |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2020-06-11 | — | — | US | disclosed |
| CN-106604916-B | Crystal form of potassium ion competitive acid retarder and preparation method thereof | 江苏豪森药业集团有限公司 | 2020-03-03 | — | — | CN | disclosed |
| CN-110200903-A | With the liquid preparation of salt stable amine and organic acid | 武田药品工业株式会社 | 2019-09-06 | — | — | CN | disclosed |
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | HENKEL AG & CO. KGAA (DE) | 2019-08-08 | — | — | US | disclosed |
| CN-102753540-B | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2014-01-22 | — | — | CN | disclosed |
| CN-102753540-A | α4β2Ligands for neuronal nicotinic acetylcholine receptors | SUVEN LIFE SCIENCES LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-102743330-A | Pharmaceutical composition | TAKEDA PHARMACEUTICAL | 2012-10-24 | — | — | CN | disclosed |
| CN-102164581-A | Pharmaceutical composition | TAKEDA PHARMACEUTICAL | 2011-08-24 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| US-6313139-B1 | ADMINISTERING BENZYLAMINE DERIVATIVE FOR THERAPY OF PSYCHIATRIC DISORDER IN MAMMALS | AKZO NOBEL N. V. (NL) | 2001-11-06 | — | — | US | disclosed |
| CN-1067991-C | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 2001-07-04 | — | — | CN | disclosed |
| CN-1161328-A | Aminoalkyl subsetd. benzo-heterocyclic compounds | HOFFMANN LA ROCHE (CH) | 1997-10-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240129-A1 | CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, S100A10 | MEN1 3369/4885KMT2A 242/4885TSHR 3146/4885 |
| US-20200179254-A1 | IMPROVED CONDITIONING HAIR TREATMENT PRODUCT WITH WASHOUT PROTECTION | KRT18, CUTA, DSG1 | MEN1 3038/4885KMT2A 59/4885TSHR 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.