Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343228 | 0.83 | ALDH1A1 (0.53) | MGAMGAASIMGAM2LTA4H | |
| SCHEMBL969040 | 0.83 | ALDH1A1 (0.52) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL14557099 | 0.81 | KDM4E (0.43) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL11431183 | 0.79 | MGAM (0.68) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL13401040 | 0.79 | KDM4E (0.64) | NPC1RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL10520010 | 0.75 | DRD1 (0.41) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL8048162 | 0.75 | P2RY1 (0.41) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL969364 | 0.74 | PTPN11 (0.47) | NPC1RAB9AALDH1A1TSHRGSTP1 | |
| SCHEMBL13801089 | 0.73 | PTGDR2 (0.52) | LTA4HNPC1RAB9ASCN4APTGDR2 | |
| SCHEMBL9341550 | 0.72 | PTPN11 (0.49) | MGAMGAASIMGAM2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |