Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290280 | 1.00 | BACE1 (0.31) | BACE1PLGGAAF2F10 | |
| SCHEMBL12606705 | 0.94 | PLG (0.32) | PLG | |
| SCHEMBL13685709 | 0.92 | CCR2 (0.33) | PLG | |
| SCHEMBL13685625 | 0.92 | CTSD (0.35) | GAA | |
| SCHEMBL8289637 | 0.92 | CTSD (0.35) | GAA | |
| SCHEMBL13685100 | 0.91 | F2 (0.33) | BACE1PLGGAAF2F10 | |
| SCHEMBL12607874 | 0.91 | ADAM17 (0.37) | — | |
| SCHEMBL8289304 | 0.89 | F2 (0.32) | BACE1PLGGAAF2F10 | |
| SCHEMBL8034474 | 0.89 | F2 (0.32) | BACE1PLGGAAF2F10 | |
| SCHEMBL12856082 | 0.89 | CTSD (0.33) | BACE1PLGGAAF2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| WO-2009058856-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |