Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP6V1B1 | P15313 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053293 | 1.00 | ATP6V1B1 (0.56) | ATP6V1B1ALDH1A1MAPK1APPMAPT | |
| SCHEMBL8053296 | 1.00 | ATP6V1B1 (0.56) | ATP6V1B1ALDH1A1MAPK1APPMAPT | |
| SCHEMBL8056516 | 0.88 | ATP6V1B1 (0.54) | ATP6V1B1ALDH1A1MAPK1APPMAPT | |
| SCHEMBL8056525 | 0.88 | ATP6V1B1 (0.54) | ATP6V1B1ALDH1A1MAPK1APPMAPT | |
| SCHEMBL8056522 | 0.88 | ATP6V1B1 (0.54) | ATP6V1B1ALDH1A1MAPK1APPMAPT | |
| SCHEMBL8343521 | 0.80 | ATP6V1B1 (0.80) | ATP6V1B1ALDH1A1MAPTHTTTP53 | |
| SCHEMBL8038935 | 0.79 | APP (0.45) | ALDH1A1APPMAPTRAB9ATAS1R3 | |
| SCHEMBL8038940 | 0.79 | APP (0.45) | ALDH1A1APPMAPTRAB9ATAS1R3 | |
| SCHEMBL8038942 | 0.79 | APP (0.45) | ALDH1A1APPMAPTRAB9ATAS1R3 | |
| SCHEMBL6291678 | 0.70 | ATP6V1B1 (0.75) | ATP6V1B1ALDH1A1APPTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025390-A | Heteroaromatic pentadienoic acid derivatives useful as inhibitors of bone resorption | SMITHKLINE BEECHAM SPA (IT) | 2000-02-15 | — | — | US | disclosed |