Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10926363 | 0.85 | TACR1 (0.41) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL8054275 | 0.84 | CTSL (0.51) | CTSLCTSSCTSKCA2CA1 | |
| SCHEMBL8041086 | 0.83 | CTSL (0.52) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL5711376 | 0.83 | CTSL (0.57) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL5711379 | 0.83 | CTSL (0.57) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL10445581 | 0.78 | CTSL (0.50) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL6348415 | 0.78 | CTSL (0.52) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL6348412 | 0.78 | CTSL (0.52) | CTSLCTSSCTSKACECTRB1 | |
| SCHEMBL8198049 | 0.75 | CTSS (0.53) | CTSLCTSSCTSKPTPN1CA2 | |
| SCHEMBL9825646 | 0.75 | CTSL (0.66) | CTSLCTSSCTSKACECTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130315-A | SUBSTRATES IN WHICH THE SCISSILE AMIDE BOND HAS BEEN REPLACED BY AN ACTIVATED ELECTROPHILIC KETONE MOIETY; ANTIINFLAMMATORY AGENTS; ANTIPROLIFERATIVE/ANTICARCINOGENIC/ANTIARTHRITIC AGENTS; TREATMENT OF AUTOIMMUNE DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849866-A | Peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1998-12-15 | — | — | US | disclosed |
| US-5496927-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE, CATHEPSIN G, CHYMOTRYPSIN | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |