SCHEMBL8053753

SCHEMBL8053753

CCCCCCCCCCCCCCC(CC(=O)O)C(=O)NCC(C(=O)NC)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 20/20 0.59
MMP3 P08254 14/20 0.59
MMP1 P03956 12/20 0.59
MMP9 P14780 2/20 0.55
MMP14 P50281 1/20 0.55
MMP7 P09237 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8060173 1.00 MMP2 (0.59) MMP2MMP3MMP1MMP9MMP14
SCHEMBL6159696 0.76 L3MBTL1 (0.44) MMP2MMP3MMP1MMP9MMP14
SCHEMBL8060171 0.74 MMP2 (1.00) MMP2MMP3MMP1MMP9MMP7
SCHEMBL8057881 0.74 MMP2 (1.00) MMP2MMP3MMP1MMP9MMP7
SCHEMBL8053894 0.74 MMP2 (1.00) MMP2MMP3MMP1MMP9MMP7
SCHEMBL8053749 0.74 MMP2 (1.00) MMP2MMP3MMP1MMP9MMP7
SCHEMBL5965918 0.74 MMP2 (0.65) MMP2MMP3MMP1MMP7
SCHEMBL23320094 0.74 ALDH1A1 (0.49) MMP2MMP3MMP1MMP9MMP14
SCHEMBL868387 0.74 POLB (0.48) MMP2MMP3MMP1MMP9MMP14
SCHEMBL989842 0.73 ASAH1 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6028110-A Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 2000-02-22 US claimed
EP-0763012-B1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARM (GB) 1999-06-09 EP claimed
EP-0763012-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-03-19 EP claimed
WO-1995032944-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1995-12-07 WO claimed
US-6028110-A Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 2000-02-22 US disclosed
EP-0763012-B1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARM (GB) 1999-06-09 EP disclosed
EP-0763012-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-03-19 EP disclosed
WO-1995032944-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1995-12-07 WO disclosed