Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081120 | 0.83 | PDE7A (0.40) | PDE7AKDM4EALDH1A1AGBL2MAPT | |
| SCHEMBL8068823 | 0.78 | PDE7A (0.40) | PDE7AKDM4EALDH1A1AGBL2MAPT | |
| SCHEMBL8054621 | 0.75 | ERN1 (0.38) | KDM4EALDH1A1MAPT | |
| SCHEMBL8066115 | 0.73 | NFE2L2 (0.45) | — | |
| SCHEMBL11819766 | 0.73 | NFE2L2 (0.45) | — | |
| SCHEMBL8066110 | 0.73 | NFE2L2 (0.45) | — | |
| SCHEMBL8064075 | 0.71 | ATM (0.38) | ALDH1A1MAPT | |
| SCHEMBL8531815 | 0.71 | SLC6A4 (0.47) | KDM4EAGBL2 | |
| SCHEMBL19914059 | 0.71 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGD | |
| SCHEMBL6077141 | 0.71 | ALDH1A1 (0.40) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6020379-A | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia | CELL PATHWAYS, INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-3954852-A | Indenylacetic acid compounds | MERCK & CO., INC. (US) | 1976-05-04 | — | — | US | disclosed |