Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8063775 | 0.82 | RARA (0.38) | ALDH1A1HTTCHRNA7MAPTTP53 | |
| SCHEMBL28376318 | 0.78 | MAPK1 (0.44) | ATMALDH1A1HTTMAPTMAPK1 | |
| SCHEMBL8068763 | 0.77 | PTPN1 (0.34) | ALDH1A1HTTCHRNA7CES2CES1 | |
| SCHEMBL8068760 | 0.77 | LMNA (0.33) | ALDH1A1HTTCHRNA7MAPTTP53 | |
| SCHEMBL11819766 | 0.75 | NFE2L2 (0.45) | — | |
| SCHEMBL8066115 | 0.75 | NFE2L2 (0.45) | — | |
| SCHEMBL8066110 | 0.75 | NFE2L2 (0.45) | — | |
| SCHEMBL8054621 | 0.74 | ERN1 (0.38) | ALDH1A1MAPT | |
| SCHEMBL17907433 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HTTMAPTMAPK1 | |
| SCHEMBL8054634 | 0.71 | PDE7A (0.35) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6020379-A | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia | CELL PATHWAYS, INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-3954852-A | Indenylacetic acid compounds | MERCK & CO., INC. (US) | 1976-05-04 | — | — | US | disclosed |