SCHEMBL8054978

SCHEMBL8054978

CCCCCCCCCCCCCCCC(CC(=O)O)C(=O)N[C@H](C(=O)NC)C(C)(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MMP3 P08254 17/20 1.00
MMP1 P03956 14/20 1.00
MMP2 P08253 13/20 1.00
MMP7 P09237 5/20 1.00
MMP9 P14780 5/20 0.76
PDF Q9HBH1 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8060175 1.00 MMP3 (1.00) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8042125 1.00 MMP3 (1.00) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8055018 0.88 MMP3 (0.78) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8042121 0.88 MMP2 (0.78) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8060190 0.87 MMP2 (0.77) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8398532 0.86 MMP3 (1.00) MMP3MMP1MMP2MMP7MMP9
SCHEMBL14545737 0.86 MMP3 (1.00) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8060154 0.86 MMP2 (0.76) MMP3MMP1MMP2MMP7MMP9
SCHEMBL14545504 0.85 MMP3 (1.00) MMP3MMP1MMP2MMP7MMP9
SCHEMBL8400277 0.84 PDF (0.90) MMP3MMP1MMP2MMP7MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6028110-A Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 2000-02-22 US claimed
EP-0763012-B1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARM (GB) 1999-06-09 EP claimed
EP-0763012-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-03-19 EP claimed
WO-1995032944-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1995-12-07 WO claimed
US-6028110-A Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 2000-02-22 US disclosed
EP-0763012-B1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARM (GB) 1999-06-09 EP disclosed
EP-0763012-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-03-19 EP disclosed
WO-1995032944-A1 SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1995-12-07 WO disclosed