Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696358 | 0.81 | IMPDH2 (0.38) | LPLLIPGALDH1A1IMPDH2MAPK14 | |
| SCHEMBL14003430 | 0.74 | S1PR4 (0.39) | ALDH1A1IMPDH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2010826 | 0.71 | ESR1 (0.39) | ESR1LPLLIPGALDH1A1IMPDH2 | |
| SCHEMBL10304989 | 0.71 | ABL1 (0.41) | ALDH1A1IMPDH2LMNACYP1A2CYP3A4 | |
| SCHEMBL20777196 | 0.71 | CSNK2A1 (0.41) | IMPDH2ADORA3CYP3A4CSNK2A1 | |
| SCHEMBL5795534 | 0.71 | ALDH1A1 (0.43) | ALDH1A1IMPDH2FYNLMNACYP3A4 | |
| SCHEMBL6980495 | 0.70 | ALDH1A1 (0.44) | ESR1ALDH1A1IMPDH2ESR2FYN | |
| SCHEMBL10035040 | 0.69 | PPARG (0.48) | ALDH1A1ERN1FYNLMNACYP1A2 | |
| SCHEMBL20036777 | 0.69 | TOP2A (0.38) | ESR1LPLLIPGALDH1A1IMPDH2 | |
| SCHEMBL11483469 | 0.69 | PTGER2 (0.38) | ESR1LPLLIPGPTGER2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105492437-A | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | KARYOPHARM THERAPEUTICS INC | 2016-04-13 | — | — | CN | disclosed |
| US-6040449-A | USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT | BANYU PHARMACEUTICAL CO LTD (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5948792-A | POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0930298-A1 | FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-07-21 | — | — | EP | disclosed |