Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 6/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15187895 | 1.00 | TSHR (0.50) | TSHRDAONAPRTSRD5A2PKM | |
| SCHEMBL19939675 | 0.94 | CA1 (0.50) | TSHRSRD5A2PKMNR4A1NR4A2 | |
| SCHEMBL18504196 | 0.94 | CA1 (0.50) | TSHRSRD5A2PKMNR4A1NR4A2 | |
| SCHEMBL15189470 | 0.93 | CES2 (0.42) | SRD5A2PKMCES2CES1ALDH1A1 | |
| SCHEMBL18504197 | 0.89 | HSD17B10 (0.51) | TSHRSRD5A2CA1CA2TP53 | |
| SCHEMBL18504198 | 0.89 | HSD17B10 (0.51) | TSHRSRD5A2CA1CA2TP53 | |
| SCHEMBL6054668 | 0.89 | CA1 (0.56) | TSHRDAONAPRTSRD5A2PKM | |
| SCHEMBL27438635 | 0.86 | BCL2L1 (0.52) | TSHRSRD5A2PKMCES2CES1 | |
| SCHEMBL27851888 | 0.85 | CA1 (0.52) | TSHRSRD5A2PKMNR4A1NR4A2 | |
| SCHEMBL17718221 | 0.83 | SRD5A2 (0.60) | TSHRSRD5A2PKMCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180067087-A1 | AMINE COMPOUND DETECTION MARKER | TOSHIBA TEC KABUSHIKI KAISHA (JP) | 2018-03-08 | — | — | US | disclosed |
| US-9279806-B2 | Water-soluble AIE luminogens for monitoring and retardation of fibrillation of amyloid proteins | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-03-08 | — | — | US | disclosed |
| US-20150031607-A1 | WATER-SOLUBLE AIE LUMINOGENS FOR MONITORING AND RETARDATION OF FIBRILLATION OF AMYLOID PROTEINS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-01-29 | — | — | US | disclosed |
| US-8679738-B2 | Water-soluble AIE luminogen for monitoring and retardation of amyloid fibrillation of insulin | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2014-03-25 | — | — | US | disclosed |
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (HK) | 2012-07-05 | — | — | US | disclosed |
| US-8129111-B2 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2012-03-06 | — | — | US | disclosed |
| US-20100009362-A1 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172296-A1 | WATER-SOLUBLE AIE LUMINOGEN FOR MONITORING AND RETARDATION OF AMYLOID FIBRILLATION OF INSULIN | IAPP, IGF2BP1, IGF2BP2 | TSHR 867/4885DAO 3952/4885NAPRT 3631/4885 |
| US-20180067087-A1 | AMINE COMPOUND DETECTION MARKER | HRH3, PHOSPHO1, HNMT | TSHR 3107/4885DAO 2160/4885NAPRT 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.