Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.77 |
| ▸ | MAOB | P27338 | 9/20 | 0.69 |
| ▸ | P4HB | P07237 | 1/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82266 | 1.00 | NFKB1 (0.77) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL29365331 | 1.00 | NFKB1 (0.77) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL82267 | 1.00 | NFKB1 (0.77) | NFKB1MAOBP4HBABCG2MAOA | |
| Hydrochloric Acid SCHEMBL6821798 | 0.98 | NFKB1 (0.74) | NFKB1MAOBP4HBABCG2MAOA | |
| Guanidine SCHEMBL8060785 | 0.91 | NFKB1 (0.64) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL6662586 | 0.88 | NFKB1 (0.65) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL7499883 | 0.88 | NFKB1 (0.60) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL5598947 | 0.87 | NFKB1 (1.00) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL5598951 | 0.87 | NFKB1 (1.00) | NFKB1MAOBP4HBABCG2MAOA | |
| SCHEMBL8634363 | 0.86 | NFKB1 (0.58) | NFKB1MAOBP4HBABCG2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025349-A | ANTIARRHYTHMIC PROPERTIES, | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0688766-B1 | Phenylsubstituted alkenyl-carboxylic-acid-guanidines containing perfluoroalkyl groups, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AG (DE) | 1999-03-24 | — | — | EP | disclosed |
| EP-0688766-A1 | Phenylsubstituted alkenyl-carboxylic-acid-guanidines containing perfluoroalkyl groups, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-27 | — | — | EP | disclosed |