Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.47 |
| ▸ | SDHB | P21912 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805589 | 0.87 | HSD11B1 (0.51) | CRHR1TRPA1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL805587 | 0.85 | HSD11B1 (0.49) | CRHR1TRPA1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL786243 | 0.80 | KMT2A (0.60) | TRPA1CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL14393909 | 0.77 | CYP1A2 (0.43) | CRHR1TRPA1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL805588 | 0.76 | USP1 (0.46) | CRHR1TRPA1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL14164025 | 0.74 | CYP1A2 (0.41) | SDHBTRPA1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5541462 | 0.74 | HSD11B1 (0.55) | TRPA1CYP2D6CYP2C19TRPM8TRPV1 | |
| SCHEMBL20782565 | 0.74 | HSD11B1 (0.51) | CRHR1TRPA1CYP1A2TRPM8TRPV1 | |
| SCHEMBL805590 | 0.74 | HSD11B1 (0.51) | TRPA1CYP1A2CYP2D6CYP2C19CYP2C9 | |
| SCHEMBL2408078 | 0.73 | CYP1A2 (0.66) | CYP1A2CYP2D6CYP2C19CYP2C9CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | CRHR1 1985/4885SDHB 4790/4885TRPA1 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.