SCHEMBL8055976

SCHEMBL8055976

O=C(O)CC(NC(=O)CC1CCc2ccccc2C1=O)C(=O)COC(=O)CC1CCc2ccccc2C1=O

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 12/20 0.43
DGAT1 O75907 1/20 0.42
ITGB3 P05106 1/20 0.40
ITGA2B P08514 1/20 0.40
ALDH1A1 P00352 2/20 0.40
CYP19A1 P11511 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TP53 P04637 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CYP26A1 O43174 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL7422490 0.89 CASP1 (0.40) CASP1DGAT1ITGB3ITGA2BALDH1A1
SCHEMBL7463690 0.88 CASP1 (0.45) CASP1DGAT1ITGB3ITGA2BALDH1A1
SCHEMBL7422485 0.87 CASP1 (0.57) CASP1ALDH1A1SMN1; SMN2
SCHEMBL7418639 0.85 CASP3 (0.42) CASP1
SCHEMBL8044063 0.83 CASP1 (0.41) CASP1
SCHEMBL7473984 0.82 CASP1 (0.45) CASP1
SCHEMBL31374633 0.74 ALDH1A1 (0.52) DGAT1ALDH1A1CYP19A1SMN1; SMN2TP53
SCHEMBL6644734 0.74 ALDH1A1 (0.52) DGAT1ALDH1A1CYP19A1SMN1; SMN2TP53
SCHEMBL8535642 0.74 CYP19A1 (0.58) DGAT1ITGB3ITGA2BALDH1A1CYP19A1
SCHEMBL7340770 0.71 ALDH1A1 (0.51) DGAT1ALDH1A1CYP19A1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0932598-A1 ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 1999-08-04 EP claimed
WO-1998016502-A1 ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 1998-04-23 WO claimed
EP-0998300-A1 METHODS AND COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS BASF AKTIENGESELLSCHAFT (DE) 2000-05-10 EP disclosed
EP-0932598-A1 ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 1999-08-04 EP disclosed
WO-1998041232-A2 COMPOSITIONS FOR MODULATING RESPONSIVENESS TO CORTICOSTEROIDS BASF AKTIENGESELLSCHAFT (DE) 1998-09-24 WO disclosed
WO-1998016502-A1 ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME WARNER-LAMBERT COMPANY (US) 1998-04-23 WO disclosed