Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | BCL9 | O00512 | 4/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066904 | 0.86 | PDE4D (0.54) | PDE4BPDE4DMAPTMEN1KMT2A | |
| SCHEMBL15906114 | 0.82 | PDE4B (0.43) | PDE4BPDE4DPTPN5ALDH1A1LMNA | |
| SCHEMBL8071935 | 0.80 | KDM1A (0.39) | PDE4DMGLLPTPN5ALDH1A1 | |
| SCHEMBL13578411 | 0.80 | PDE4B (0.40) | PDE4BPDE4DSYKPTPN5FAAH | |
| SCHEMBL3793991 | 0.77 | PDE4B (0.49) | PDE4BPDE4DALDH1A1MAPTMEN1 | |
| SCHEMBL8071506 | 0.74 | PDE4B (0.48) | PDE4BPDE4DMAPTMEN1KMT2A | |
| SCHEMBL8062938 | 0.73 | PDE4B (0.47) | PDE4BPDE4DMAPTMEN1KMT2A | |
| SCHEMBL7913226 | 0.73 | PDE4D (0.76) | PDE4BPDE4DFAAHHTTALDH1A1 | |
| SCHEMBL8069097 | 0.72 | PDE4D (0.49) | PDE4BPDE4D | |
| SCHEMBL8071940 | 0.71 | PDE4D (0.51) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |