Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071506 | 0.88 | PDE4B (0.48) | PDE4DPDE4BHTR7STK10SLK | |
| SCHEMBL8062938 | 0.86 | PDE4B (0.47) | PDE4DPDE4BHTR7STK10SLK | |
| SCHEMBL8056450 | 0.86 | PDE4B (0.41) | PDE4DPDE4BMEN1KMT2AMAPT | |
| SCHEMBL8071940 | 0.85 | PDE4D (0.51) | PDE4DPDE4BHTR7FFAR1HDAC4 | |
| SCHEMBL8069097 | 0.85 | PDE4D (0.49) | PDE4DPDE4BHTR7CASRFFAR1 | |
| SCHEMBL8066338 | 0.84 | PDE4D (0.53) | PDE4DPDE4BHTR7FFAR1HDAC4 | |
| SCHEMBL8071935 | 0.82 | KDM1A (0.39) | PDE4DCA2 | |
| SCHEMBL8066867 | 0.82 | PDE4B (0.46) | PDE4DPDE4BHTR7FFAR1MEN1 | |
| SCHEMBL15906113 | 0.82 | PDE4D (0.49) | PDE4DPDE4BHTR7CASRMEN1 | |
| SCHEMBL8014205 | 0.82 | PDE4B (0.46) | PDE4DPDE4BHTR7FFAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |