Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066338 | 0.87 | PDE4D (0.53) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8066904 | 0.85 | PDE4D (0.54) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL15906108 | 0.84 | PDE4D (0.48) | PDE4DCALM1PDE4BHTR7HDAC4 | |
| SCHEMBL8065375 | 0.83 | PDE4D (0.47) | PDE4DCALM1PDE4BHTR7HDAC4 | |
| SCHEMBL8014205 | 0.82 | PDE4B (0.46) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8066867 | 0.82 | PDE4B (0.46) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8067030 | 0.82 | PDE4D (0.49) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8065317 | 0.81 | PDE4D (0.47) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8071506 | 0.81 | PDE4B (0.48) | PDE4DPDE4BHTR7HDAC4HDAC2 | |
| SCHEMBL8069097 | 0.81 | PDE4D (0.49) | PDE4DPDE4BHTR7HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |