Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065375 | 0.88 | PDE4D (0.47) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8066904 | 0.88 | PDE4D (0.54) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL15906104 | 0.85 | PDE4B (0.46) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8065317 | 0.81 | PDE4D (0.47) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL13578416 | 0.81 | PDE4B (0.42) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8071940 | 0.81 | PDE4D (0.51) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8069097 | 0.80 | PDE4D (0.49) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL3792967 | 0.80 | CYP19A1 (0.48) | PDE4BPDE4DMEN1MAPTKMT2A | |
| SCHEMBL8066925 | 0.80 | PDE4D (0.48) | PDE4BPDE4DHDAC4HDAC2HDAC8 | |
| SCHEMBL8062938 | 0.79 | PDE4B (0.47) | PDE4BPDE4DHTR7MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |