Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.60 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.56 |
| ▸ | WNT1 | P04628 | 5/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6951767 | 0.86 | NPC1 (0.64) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL4384530 | 0.86 | NPC1 (0.82) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL6954648 | 0.84 | HTR1A (0.65) | NPC1RAB9AHTR1ADRD2HTR2A | |
| SCHEMBL6950689 | 0.84 | NPC1 (0.74) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL29732688 | 0.84 | NPC1 (0.74) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL3164026 | 0.83 | WNT1 (0.69) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL8162625 | 0.83 | NPC1 (0.65) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL6951433 | 0.80 | NPC1 (0.68) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL7376957 | 0.80 | RAB9A (0.54) | NPC1RAB9ASMYD3USP30DYRK1A | |
| SCHEMBL26400414 | 0.79 | NPC1 (0.97) | NPC1RAB9ASMYD3USP30DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117882-A | 5-HT4 agonists and antagonists | ELI LILLY AND COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| US-6069152-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0908459-A1 | 5-HT4 Agonists and antagonists | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |