SCHEMBL8045546

SCHEMBL8045546

NC1=NC(c2ccco2)Cc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 17/20 1.00
NOS2 P35228 13/20 1.00
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8097995 0.98 NOS3 (0.97) NOS3NOS2ALDH1A1MAPTTDP1
SCHEMBL8056719 0.77 NOS3 (0.63) NOS3NOS2ALDH1A1MAPTTDP1
Hydrochloric Acid SCHEMBL8090620 0.76 NOS3 (0.61) NOS3NOS2ALDH1A1MAPTTDP1
SCHEMBL251337 0.76 NOS3 (1.00) NOS3NOS2
SCHEMBL8057607 0.75 NOS2 (1.00) NOS3NOS2ALDH1A1MAPTTDP1
SCHEMBL8060942 0.75 NOS3 (0.68) NOS3NOS2
Hydrochloric Acid SCHEMBL8100105 0.74 NOS2 (0.97) NOS3NOS2ALDH1A1MAPTTDP1
Hydrochloric Acid SCHEMBL8097464 0.74 NOS3 (0.97) NOS3NOS2TSHR
Hydrochloric Acid SCHEMBL8099664 0.74 NOS3 (0.66) NOS3NOS2TSHR
SCHEMBL8056685 0.72 NOS3 (0.79) NOS3NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP claimed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US claimed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO claimed
EP-0892784-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS Astra Pharmaceuticals Limited (GB) 1999-01-27 EP claimed
WO-1997038977-A1 AMINOISOQUINOLINES AND AMINOTHIENOPYRIDINE DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS ASTRA PHARMACEUTICALS LTD. (GB) 1997-10-23 WO claimed
EP-1027052-A1 NOVEL COMBINATION AstraZeneca UK Limited (GB) 2000-08-16 EP disclosed
US-6046191-A PHARMACEUTICAL COMBINATION COMPRISING A COX-2 INHIBITOR OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND AN AMIDINE COMPOUND; FOR TREATMENT OF INFLAMMATORY DISORDERS ASTRA PHARMACEUTICALS LTD. (GB) 2000-04-04 US disclosed
WO-1999018960-A1 NOVEL COMBINATION ASTRAZENECA UK LIMITED (GB) 1999-04-22 WO disclosed