Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059141 | 0.80 | HPGD (0.43) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8059152 | 0.76 | HPGD (0.41) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL8058466 | 0.75 | HPGD (0.41) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7633968 | 0.73 | KIF11 (0.43) | ALDH1A1KMT2ATDP1NPC1RAB9A | |
| SCHEMBL8058503 | 0.72 | HPGD (0.46) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL7639980 | 0.72 | GAA (0.41) | ALDH1A1NPC1RAB9AKIF11 | |
| SCHEMBL6270462 | 0.72 | CHRM2 (0.45) | EPHX2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL7644315 | 0.71 | GRM2 (0.44) | TDP1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3999140 | 0.70 | KEAP1 (0.43) | EPHX2KEAP1NFE2L2ALDH1A1MEN1 | |
| SCHEMBL8059180 | 0.69 | GRM2 (0.45) | CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | claimed |