Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | CTH | P32929 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982231 | 0.93 | — | — | |
| SCHEMBL352177 | 0.93 | — | — | |
| SCHEMBL591208 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL6901823 | 0.91 | ACHE (0.45) | ACHECTHGAAKDM4EALDH1A1 | |
| Bromide SCHEMBL28108732 | 0.91 | ACHE (0.45) | ACHECTHGAAKDM4EALDH1A1 | |
| Bromide SCHEMBL7180391 | 0.91 | ACHE (0.45) | ACHECTHGAAKDM4EALDH1A1 | |
| SCHEMBL29720380 | 0.84 | KMT2A (0.44) | ACHECTHGAAKMT2ANPC1 | |
| SCHEMBL9712709 | 0.84 | KMT2A (0.44) | ACHECTHGAAKMT2ANPC1 | |
| Isonicotinonitrile SCHEMBL27701693 | 0.78 | GRK2 (0.48) | ACHECTHGAAKDM4EALDH1A1 | |
| SCHEMBL5668373 | 0.74 | KMT2A (0.64) | ACHEGAAKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166032-A | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 2000-12-26 | — | — | US | claimed |
| US-6166032-A | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 2000-12-26 | — | — | US | disclosed |
| EP-1014981-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF SYNAPTIC DYSFUNCTION COMPRISING AN OXIME | Synapse Pharmaceuticals International, Inc. (CA) | 2000-07-05 | — | — | EP | disclosed |
| US-5981549-A | Method for controlling or alleviating the symptoms of respiratory disease and allergies | SYNAPSE PHARMACEUTICAL INTERNATIONAL (CA) | 1999-11-09 | — | — | US | disclosed |
| US-5916903-A | Method for reducing the effects of antineoplastic disease treatment | SYNAPSE PAHRMACEUTICALS INTERNATIONAL, INC. (CA) | 1999-06-29 | — | — | US | disclosed |
| US-5902816-A | Method for treatment of heavy metal poisoning | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 1999-05-11 | — | — | US | disclosed |
| US-5900418-A | Method for treatment of obesity | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 1999-05-04 | — | — | US | disclosed |
| US-5824684-A | Method for treating drug and alcohol addiction | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 1998-10-20 | — | — | US | disclosed |
| WO-1998034615-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF SYNAPTIC DYSFUNCTION COMPRISING AN OXIME | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 1998-08-13 | — | — | WO | disclosed |
| US-5760049-A | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use | SYNAPSE PHARMACEUTICALS INTERNATIONAL, INC. (CA) | 1998-06-02 | — | — | US | disclosed |