Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL8482977 | 0.94 | DNMT1 (0.37) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL93807 | 0.94 | DNMT1 (0.37) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL207077 | 0.93 | DNMT1 (0.36) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL9125279 | 0.93 | DNMT1 (0.36) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL5697804 | 0.91 | MAPT (0.38) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL626502 | 0.91 | DNMT1 (0.35) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL17609997 | 0.90 | MAPT (0.37) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL8429242 | 0.88 | MAPT (0.36) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL6259658 | 0.85 | MAPT (0.41) | MAPTHTTTP53STAT3SMN1; SMN2 | |
| Triaziquone SCHEMBL3641977 | 0.85 | DNMT1 (0.31) | MAPTHTTTP53STAT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998564-A1 | MCP-1 ANALOGS | ZENECA LIMITED (GB) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999005279-A1 | MCP-1 ANALOGS | ZENECA LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |