Triaziquone

Triaziquone

SCHEMBL93807

NC(CO)(CO)CO.O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1

nearest known ligand 0.37

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA

The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DNMT1 P26358 1/20 0.37
TP53 P04637 1/20 0.35
MAPT P10636 1/20 0.35
STAT3 P40763 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
APAF1 O14727 1/20 0.31
TDP2 O95551 1/20 0.31
NSD2 O96028 1/20 0.31
HKDC1 Q2TB90 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triaziquone SCHEMBL8482977 1.00 DNMT1 (0.37) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL9125279 0.98 DNMT1 (0.36) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL207077 0.98 DNMT1 (0.36) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL626502 0.97 DNMT1 (0.35) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL8058737 0.94 MAPT (0.35) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL5697804 0.94 MAPT (0.38) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL6259658 0.90 MAPT (0.41) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL3641977 0.90 DNMT1 (0.31) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL16684529 0.89 MAPT (0.40) DNMT1TP53MAPTSTAT3HTT
Triaziquone SCHEMBL17609997 0.89 MAPT (0.37) DNMT1TP53MAPTSTAT3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3739 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4392779-A1 A METHOD OF DETERMINING AN IMMUNOGENIC RESPONSE CHARACTERISTIC OF A CHEMICAL SUBSTANCE Fida Biosystems ApS (DK) 2024-07-03 EP claimed
US-12012574-B2 Process for removing dry surface biofilm WHITELEY CORPORATION PTY. LTD. (AU) 2024-06-18 US claimed
US-20240189242-A1 LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF FORMULATING THE SAME MODERNATX, INC. (US) 2024-06-13 US claimed
WO-2024096378-A1 METHOD FOR PURIFYING TGF-β3 PROTEIN 주식회사 대웅제약 2024-05-10 WO claimed
WO-2024044147-A1 METHODS FOR PURIFICATION OF IONIZABLE LIPIDS MODERNATX, INC. (US) 2024-02-29 WO claimed
US-20240016827-A1 LIPID NANOPARTICLE COMPOSITIONS AND METHODS OF FORMULATING THE SAME MODERNATX, INC. (US) 2024-01-18 US claimed
US-20230384188-A1 ROOM TEMPERATURE STABLE, DRY BIOLOGICAL TRANSPORT MEDIA GENTEGRA, LLC 2023-11-30 US claimed
WO-2023227505-A1 LIQUID PHARMACEUTICAL FORMULATIONS OF CNP COMPOUNDS ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) 2023-11-30 WO claimed
US-20230293735-A1 OXINE-CONTAINING CELL RADIOLABELLING AGENTS KING S COLLEGE LONDON (GB) 2023-09-21 US claimed
EP-4242298-A2 NANOPARTICLE FORMULATIONS Taiga Biotechnologies, Inc. (US) 2023-09-13 EP claimed
US-20070054342-A1 Luciferase detection assay system REVVITY HEALTH SCIENCES B.V. (NL) 2007-03-08 US claimed
WO-2006121331-A1 USE OF AMMONIUM AND PHOSPHATE IONS FOR IMPROVING THE DETECTION OF LUCIFERASE PERKINELMER LIFE AND ANALYTICAL SCIENCES B.V. (NL) 2006-11-16 WO claimed
WO-2006076663-A2 KITS AND IMPROVED COMPOSITIONS FOR TREATING LOWER URINARY TRACT URIGEN, INC. (US) 2006-07-20 WO claimed
US-20060127477-A1 Novel preparation and administration form comprising an acid-labile active compound ALTANA PHARMA AG 2006-06-15 US claimed
EP-1616562-A1 NOVEL PREPARATION AND ADMINISTRATION FORM COMPRISING AN ACID-LABILE ACTIVE COMPOUND ALTANA Pharma AG (DE) 2006-01-18 EP claimed
US-20050214885-A1 Method for detecting mild impaired glucose tolerance or insulin hyposecretion ASAHI KASEI PHARMA CORPORATION (JP) 2005-09-29 US claimed
EP-1187601-B1 NOVEL PREPARATION AND ADMINISTRATION FORM COMPRISING AN ACID-LABILE PROTON PUMP INHIBITOR ALTANA PHARMA AG (DE) 2005-07-27 EP claimed
EP-0999275-B1 Deoxynucleoside kinase from insect cells for the synthesis of nucleoside monophosphates ROCHE DIAGNOSTICS GMBH (DE) 2005-01-19 EP claimed
US-20020182600-A1 Method for assaying biological and other constituents using synthetic nucleounits in lateral flow, liquid, and dry chemistry techniques SMITH JACK V (US) 2002-12-05 US claimed
EP-0571593-B1 NEW NON IONIC IODIZED AGENTS FOR X-RAY CONTRASTING, METHOD FOR PREPARING THEM AND GALENICAL COMPOSITIONS CONTAINING THEM INVEST JUSTESA IMAGEN S A CENT (ES) 1996-10-30 EP claimed