Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900253 | 0.61 | HSP90AA1 (0.37) | SIGMAR1ADRA2ATMEM97HTR2A | |
| SCHEMBL30861792 | 0.61 | HSP90AA1 (0.37) | SIGMAR1ADRA2ATMEM97HTR2A | |
| SCHEMBL7719400 | 0.60 | NOTUM (0.36) | SIGMAR1ADRA2A | |
| SCHEMBL29710415 | 0.58 | ALDH1A1 (0.33) | SIGMAR1ALDH1A1MAPTHTR2A | |
| SCHEMBL11669847 | 0.57 | ALDH1A1 (0.38) | ALDH1A1MAPTITGA4HTR2A | |
| SCHEMBL21192353 | 0.57 | CA1 (0.38) | ALDH1A1HTR2A | |
| SCHEMBL11669842 | 0.57 | ALDH1A1 (0.38) | ALDH1A1MAPTITGA4HTR2A | |
| SCHEMBL19766703 | 0.57 | CA1 (0.38) | ALDH1A1HTR2A | |
| SCHEMBL12310582 | 0.57 | HTR2A (0.36) | ADRA2AHTR2A | |
| SCHEMBL24272873 | 0.56 | MPO (0.32) | ALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062214-A1 | SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFA LEVELS | CELGENE CORPORATION (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046258-A1 | SUBSTITUTED 2-(2,6-DIOXO-3-FLUOROPIPERIDIN-3-YL)-ISOINDOLINES AND THEIR USE TO REDUCE TNFα LEVELS | CELGENE CORPORATION (US) | 1999-09-16 | — | — | WO | disclosed |