SCHEMBL8059476

SCHEMBL8059476

O=C(OCc1ccccc1)C(CC1CCC1)C(=O)OCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2C9 P11712 1/20 0.50
TSHR P16473 2/20 0.47
ALDH1A1 P00352 6/20 0.46
CTSL P07711 1/20 0.46
CTSB P07858 1/20 0.46
CTSS P25774 1/20 0.46
CTSK P43235 1/20 0.46
MAPK1 P28482 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SLC6A2 P23975 1/20 0.45
SLC6A3 Q01959 1/20 0.45
KMT2A Q03164 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
GAA P10253 1/20 0.43
EPHX1 P07099 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24405105 0.89 CTSB (0.51) CYP2C19CYP3A4CYP2C9ALDH1A1CTSL
SCHEMBL6914473 0.85 CYP3A4 (0.65) CYP2C19CYP3A4CYP2C9TSHRALDH1A1
SCHEMBL8096744 0.83 CYP3A4 (0.49) CYP2C19CYP3A4CYP2C9TSHRALDH1A1
SCHEMBL8096746 0.83 CYP3A4 (0.49) CYP2C19CYP3A4CYP2C9TSHRALDH1A1
SCHEMBL8059473 0.82 CYP3A4 (0.46) CYP2C19CYP3A4CYP2C9TSHRALDH1A1
SCHEMBL13017759 0.82 CTSB (0.49) CYP2C19CYP3A4CYP2C9ALDH1A1CTSL
SCHEMBL5981841 0.82 CTSB (0.49) CYP2C19CYP3A4CYP2C9ALDH1A1CTSL
SCHEMBL7442293 0.82 CTSB (0.49) CYP2C19CYP3A4CYP2C9ALDH1A1CTSL
SCHEMBL6473457 0.82 IDO1 (0.53) CYP2C19CYP3A4CYP2C9TSHRALDH1A1
SCHEMBL6479809 0.81 IDO1 (0.52) CYP2C19CYP3A4CYP2C9TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6066662-A USE IN CONTROL OR PREVENTION OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS OR IN THE TREATMENT OF INVASIVE TUMOURS, ATHEROSCLEROSIS OR MULTIPLE SCLEROSIS HOFFMANN-LA ROCHE INC. (US) 2000-05-23 US disclosed
EP-0763013-A1 HYDROXYLAMINE DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1997-03-19 EP disclosed
WO-1995033709-A1 HYDROXYLAMINE DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1995-12-14 WO disclosed