SCHEMBL8059528

SCHEMBL8059528

C#CCc1cc[c]c(C)c1/C=N\O

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.33
GFER P55789 1/20 0.33
HTT P42858 2/20 0.31
ALOX15 P16050 1/20 0.31
PTGS2 P35354 1/20 0.31
LMNA P02545 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8059533 0.78 MEN1 (0.35) HPGDGFERHTTALOX15LMNA
SCHEMBL8059571 0.70 HPGD (0.33) HPGDLMNA
SCHEMBL15067322 0.64 FGF23 (0.43) HPGDHTTLMNASMN1; SMN2
SCHEMBL15067321 0.64 FGF23 (0.43) HPGDHTTLMNASMN1; SMN2
SCHEMBL15067098 0.60 HPGD (0.35) HPGDGFERHTTALOX15LMNA
SCHEMBL15067627 0.60 ACHE (0.36) HPGDGFERHTTALOX15LMNA
SCHEMBL15067097 0.60 HPGD (0.35) HPGDGFERHTTALOX15LMNA
SCHEMBL15067628 0.60 ACHE (0.36) HPGDGFERHTTALOX15LMNA
SCHEMBL5803088 0.59 HPGD (0.46) HPGDGFERHTTALOX15LMNA
SCHEMBL5803087 0.59 HPGD (0.46) HPGDGFERHTTALOX15LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015412-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AG (DE) 2000-07-05 EP disclosed
EP-1015420-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AG (DE) 2000-07-05 EP disclosed
WO-1999012892-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed
WO-1999012885-A1 SUBSTITUTED ALKENOIC ACIDS AND THEIR DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed