SCHEMBL8059640

SCHEMBL8059640

O=C(/C=C/c1ccc(F)cc1)Nc1cccc(C(=O)O)c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 1/20 0.76
MMP1 P03956 8/20 0.67
MMP2 P08253 8/20 0.67
MMP9 P14780 8/20 0.67
EGFR P00533 2/20 0.63
MAPT P10636 3/20 0.63
ATM Q13315 2/20 0.63
RECQL P46063 1/20 0.63
MEN1 O00255 2/20 0.62
KMT2A Q03164 2/20 0.62
MAOB P27338 1/20 0.60
SMN1; SMN2 Q16637 3/20 0.59
LMNA P02545 2/20 0.59
ALDH1A1 P00352 1/20 0.59
SNCA P37840 1/20 0.59
TP53 P04637 1/20 0.58
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
MET P08581 2/20 0.57
PTGS2 P35354 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8059642 1.00 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8049032 0.89 LTB4R (0.84) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8049033 0.89 LTB4R (0.84) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8065891 0.88 MMP1 (0.73) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8065890 0.88 MMP1 (0.73) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8060579 0.86 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8060331 0.86 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8048917 0.86 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8060333 0.86 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR
SCHEMBL8048920 0.86 LTB4R (0.76) LTB4RMMP1MMP2MMP9EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed