SCHEMBL8065890

SCHEMBL8065890

O=C(/C=C/c1cccc(F)c1)Nc1cccc(C(=O)O)c1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 8/20 0.73
MMP2 P08253 8/20 0.73
MMP9 P14780 8/20 0.73
LTB4R Q15722 1/20 0.67
MAOB P27338 2/20 0.64
KDM4E B2RXH2 1/20 0.62
NPC1 O15118 1/20 0.62
RAB9A P51151 1/20 0.62
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
CA12 O43570 2/20 0.59
CA9 Q16790 2/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
HDAC3 O15379 1/20 0.57
HDAC4 P56524 1/20 0.57
HDAC1 Q13547 1/20 0.57
HDAC7 Q8WUI4 1/20 0.57
HDAC2 Q92769 1/20 0.57
HDAC8 Q9BY41 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8065891 1.00 MMP1 (0.73) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL8059642 0.88 LTB4R (0.76) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL8059640 0.88 LTB4R (0.76) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL8049032 0.88 LTB4R (0.84) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL8049033 0.88 LTB4R (0.84) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL6013373 0.85 MMP1 (0.79) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL6013371 0.85 MMP1 (0.79) MMP1MMP2MMP9LTB4RMAOB
SCHEMBL705746 0.85 MMP1 (1.00) MMP1MMP2MMP9MAOBNPC1
SCHEMBL705745 0.85 MMP1 (1.00) MMP1MMP2MMP9MAOBNPC1
SCHEMBL8065865 0.84 MAOB (0.73) MMP1MMP2MMP9LTB4RMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed