Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB9 | P28065 | 12/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.39 |
| ▸ | PPIA | P62937 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048196 | 0.80 | HDAC4 (0.33) | PPIAHDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL14093947 | 0.68 | NPSR1 (0.33) | PSMB8PSMB5 | |
| SCHEMBL8054549 | 0.67 | PPIA (0.33) | PPIAHDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL13881319 | 0.65 | ADAM17 (0.36) | PSMB5HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL12607958 | 0.65 | — | — | |
| SCHEMBL8290722 | 0.64 | CTSD (0.34) | HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL20611469 | 0.63 | HDAC4 (0.53) | HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL8291503 | 0.62 | F2 (0.41) | HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL12856045 | 0.62 | HDAC4 (0.40) | HDAC6HDAC1HDAC3HDAC4 | |
| SCHEMBL19978420 | 0.62 | HDAC1 (0.51) | HDAC6HDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058856-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |