Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 14/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | KLHL20 | Q9Y2M5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12253516 | 0.78 | KLHL20 (0.37) | HDAC4HDAC1HDAC6KLHL20 | |
| SCHEMBL8291443 | 0.78 | F2 (0.43) | HDAC4HDAC1HDAC6 | |
| SCHEMBL8046504 | 0.74 | — | — | |
| SCHEMBL12527909 | 0.72 | HDAC4 (0.45) | HDAC4HDAC1HDAC6MEN1SMN1; SMN2 | |
| SCHEMBL8249283 | 0.71 | TERF2 (0.35) | HDAC4HDAC1HDAC6 | |
| SCHEMBL16349811 | 0.69 | F2 (0.42) | HDAC4HDAC1HDAC6 | |
| SCHEMBL14952755 | 0.68 | SMN1; SMN2 (0.51) | HDAC4HDAC1HDAC6SMN1; SMN2HDAC3 | |
| SCHEMBL7252962 | 0.68 | KDM4E (0.43) | HDAC4HDAC1MEN1SMN1; SMN2 | |
| SCHEMBL12784133 | 0.67 | MEN1 (0.33) | MEN1 | |
| SCHEMBL16349737 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664092-B1 | MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORP (US) | 2011-02-02 | — | — | EP | disclosed |