SCHEMBL8059984

SCHEMBL8059984

Cc1c(Cl)ccnc1C[S+]([O-])c1nc2cc(-n3ccnc3)c(F)cc2[nH]1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CD38 P28907 3/20 0.36
F9 P00740 1/20 0.34
CGAS Q8N884 1/20 0.33
IDH1 O75874 1/20 0.33
BDKRB2 P30411 1/20 0.30
CYP19A1 P11511 1/20 0.30
P2RX7 Q99572 1/20 0.30
ADH5 P11766 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8069198 0.88 ATP4A (0.41) CD38CGASCYP19A1
SCHEMBL8071088 0.85 NPC1 (0.39) CYP19A1
SCHEMBL8074026 0.85 WDR5 (0.39) CD38CGASCYP19A1
SCHEMBL8059870 0.82 BRS3 (0.36) CYP19A1
SCHEMBL8069352 0.82 CYP19A1 (0.41) CD38CGASCYP19A1
SCHEMBL8070793 0.80 OPRL1 (0.44) CD38F9CGAS
SCHEMBL8069345 0.80 CYP11B1 (0.38) CGASCYP19A1
SCHEMBL8977408 0.78 ATP4A (0.43)
SCHEMBL8977272 0.77 ATP4A (0.42)
SCHEMBL8977271 0.75 ATP1A1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US claimed
US-6051570-A ANTIULCER AGENTS DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-04-18 US disclosed
EP-0983263-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-03-08 EP disclosed
WO-1998054172-A1 NOVEL BENZIMIDAZOLE DERIVATIVES AS ANTIULCER AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1998-12-03 WO disclosed