Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061148 | 0.90 | SRC (0.43) | MAPTRAPGEF3ELANEKDM4ESMN1; SMN2 | |
| Water SCHEMBL8066910 | 0.86 | KDM4E (0.49) | ELANEKDM4ECYP1A2CYP2C19S1PR1 | |
| SCHEMBL8060667 | 0.86 | KDM4E (0.49) | ELANEKDM4ECYP1A2CYP2C19S1PR1 | |
| SCHEMBL8060382 | 0.83 | KDM4E (0.46) | MAPTRAPGEF3ELANEKDM4ESMN1; SMN2 | |
| SCHEMBL8060286 | 0.83 | HTR3A (0.45) | MAPTELANEKDM4ESMN1; SMN2LMNA | |
| SCHEMBL8131769 | 0.80 | SRC (0.37) | MAPTELANEKDM4ECYP1A2CYP2C19 | |
| SCHEMBL8061142 | 0.78 | KDM4E (0.44) | MAPTELANEIMPDH2KDM4EKMT2A | |
| SCHEMBL8060295 | 0.78 | RAPGEF3 (0.48) | MAPTRAPGEF3ELANEKDM4ECYP1A2 | |
| SCHEMBL8066629 | 0.78 | DHODH (0.41) | MAPTELANEIMPDH2SMN1; SMN2KMT2A | |
| SCHEMBL8066627 | 0.78 | DHODH (0.41) | MAPTELANEIMPDH2SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | claimed |
| EP-1001941-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006375-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS KYNURENINE-3-HYDROXYLASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-02-11 | — | — | WO | disclosed |