Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 2/20 | 0.36 |
| ▸ | PGK2 | P07205 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187685 | 0.82 | CYP2C19 (0.46) | HDAC6HDAC1HDAC3HDAC2HTT | |
| SCHEMBL8345266 | 0.78 | RIPK1 (0.34) | ACP3RAB9ARIPK1CES2CES1 | |
| SCHEMBL5643335 | 0.76 | KCNN4 (0.47) | KCNN4HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL6237816 | 0.74 | HDAC6 (0.36) | KCNN4HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL9681178 | 0.73 | L3MBTL1 (0.40) | CA12CA9CA14 | |
| SCHEMBL777721 | 0.72 | KCNN4 (0.49) | KCNN4HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL1522028 | 0.71 | KCNN4 (0.47) | KCNN4HDAC6HDAC1HDAC3HDAC2 | |
| SCHEMBL5644900 | 0.70 | MAPT (0.45) | KCNN4CES2CES1ACHE | |
| SCHEMBL9229179 | 0.70 | ACP3 (0.47) | CA12MMP2CA14ACP3 | |
| SCHEMBL777635 | 0.69 | NPC1 (0.44) | KCNN4HDAC6HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014991-A1 | PROSTAGLANDIN DERIVATIVES DEVOID OF SIDE-EFFECTS FOR THE TREATMENT OF GLAUCOMA | Pharmacia & Upjohn AB (SE) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999002165-A1 | PROSTAGLANDIN DERIVATIVES DEVOID OF SIDE-EFFECTS FOR THE TREATMENT OF GLAUCOMA | PHARMACIA & UPJOHN AB (SE) | 1999-01-21 | — | — | WO | disclosed |