Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054302 | 1.00 | LRRK2 (0.41) | LRRK2ALDH1A1HTR1AHTR1DCCR6 | |
| SCHEMBL8050815 | 0.86 | P2RX7 (0.46) | ALDH1A1HTR1AHTR1DGAAMAPT | |
| SCHEMBL12162969 | 0.72 | ITGB2 (0.43) | LRRK2CCR6TRPV1MAPK1LMNA | |
| SCHEMBL6431777 | 0.71 | ITGB2 (0.46) | LRRK2TRPV1MAPK1LMNAHTR2A | |
| SCHEMBL5017486 | 0.71 | ITGB2 (0.46) | LRRK2TRPV1MAPK1LMNAHTR2A | |
| SCHEMBL4740571 | 0.70 | FADS1 (0.62) | LRRK2ALDH1A1CCR6MAPTTRPV1 | |
| SCHEMBL599753 | 0.70 | LRRK2 (0.46) | LRRK2CCR6TRPV1MAPK1HTR2A | |
| SCHEMBL22997177 | 0.69 | PDPK1 (0.52) | HTR2A | |
| SCHEMBL7500388 | 0.69 | PDPK1 (0.52) | HTR2A | |
| SCHEMBL2790683 | 0.69 | ITGB2 (0.43) | LRRK2TRPV1MAPK1LMNAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |