Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054302 | 0.86 | LRRK2 (0.41) | P2RX7ALDH1A1GAAMAPTHTR1A | |
| SCHEMBL8060412 | 0.86 | LRRK2 (0.41) | P2RX7ALDH1A1GAAMAPTHTR1A | |
| SCHEMBL3829666 | 0.71 | P2RX7 (0.45) | P2RX7DRD2DRD3MAPK1LTB4R | |
| SCHEMBL3409292 | 0.68 | PLAU (0.39) | P2RX7ALDH1A1GAAMAPTHTR1A | |
| SCHEMBL3404302 | 0.68 | BACE1 (0.37) | P2RX7ALDH1A1MAPTHTR1AKDM4E | |
| SCHEMBL6369306 | 0.67 | ADRA2A (0.58) | P2RX7HTR1ACYP2D6LTB4RLTB4R2 | |
| SCHEMBL22655135 | 0.67 | GAA (0.52) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL29565663 | 0.67 | GAA (0.52) | ALDH1A1GAAMAPTKDM4ELMNA | |
| SCHEMBL24915634 | 0.67 | LTB4R (0.45) | P2RX7CYP2D6SLC6A2SLC6A4DRD2 | |
| SCHEMBL506553 | 0.67 | PDPK1 (0.46) | CYP2D6SLC6A2SLC6A4LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |