Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | C5AR1 | P21730 | 3/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | HPD | P32754 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059497 | 0.89 | OPRL1 (0.48) | OPRL1OPRM1OPRK1OPRD1C5AR1 | |
| SCHEMBL8478720 | 0.86 | CACNA1G (0.52) | OPRL1OPRM1OPRK1C5AR1CACNA1G | |
| SCHEMBL7586868 | 0.85 | OPRL1 (0.48) | OPRL1OPRM1OPRK1OPRD1C5AR1 | |
| SCHEMBL2604460 | 0.84 | OPRL1 (0.61) | OPRL1OPRM1OPRK1OPRD1C5AR1 | |
| SCHEMBL2604459 | 0.84 | OPRL1 (0.61) | OPRL1OPRM1OPRK1OPRD1C5AR1 | |
| SCHEMBL8062930 | 0.83 | OPRM1 (0.46) | OPRL1OPRM1OPRK1OPRD1HPD | |
| SCHEMBL8058238 | 0.83 | CACNA1G (0.48) | OPRL1OPRM1OPRK1C5AR1CACNA1G | |
| SCHEMBL14198897 | 0.83 | OPRL1 (0.43) | OPRL1OPRM1OPRK1C5AR1CACNA1G | |
| SCHEMBL5389259 | 0.83 | C5AR1 (0.62) | OPRL1OPRM1OPRK1OPRD1C5AR1 | |
| SCHEMBL2482744 | 0.82 | CYP3A4 (0.52) | OPRL1OPRM1OPRK1OPRD1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096763-A | ADMINISTERING TO THE PATIENTS A2-OXO-1-BENZIMIDAZOLINYL)PIPERIDIN-1-YL)ALKYL)-1,2BENZISOTHIA ZOL-3-(2H)-ONE DERIVATIVE AS ALPHA-1A ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 2000-08-01 | — | — | US | disclosed |
| US-5952351-A | DERIVATIVES OF 1,1,3-TRIOXO-2-((2-OXOBENZIMIDAZOLIN- OR BENZOXAZOLIN-2-YL)-PIPERIDIN-4,1-YLENE-)-1,2-BENZISOTHIAZOLE; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA; SELECTIVE RELAXATION OF SMOOTH MUSCLE WITHOUT INDUCING HYPOTENSION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0812196-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0812196-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996025934-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |
| US-3996362-A | ANTIDEPRESSANTS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-12-07 | — | — | US | disclosed |