SCHEMBL8060436

SCHEMBL8060436

C=C(CC(=O)Nc1ccccc1C(=O)OC)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.60
TSHR P16473 3/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C19 P33261 1/20 0.53
ALDH1A1 P00352 6/20 0.50
HSD17B10 Q99714 3/20 0.50
KDM4E B2RXH2 3/20 0.50
MAPK10 P53779 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.48
ELANE P08246 1/20 0.47
PRTN3 P24158 1/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
RORC P51449 1/20 0.46
APOBEC3A P31941 1/20 0.46
APOBEC3G Q9HC16 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8059534 0.86 TRPA1 (0.54) KMT2AALDH1A1L3MBTL1
SCHEMBL8691529 0.80 ALDH1A1 (0.60) KMT2ATSHRCYP1A2CYP2D6CYP2C19
SCHEMBL22497429 0.80 KDM4E (0.74) KMT2ATSHRALDH1A1HSD17B10KDM4E
SCHEMBL8689099 0.79 L3MBTL1 (0.75) KMT2ATSHRCYP1A2CYP2C19ALDH1A1
SCHEMBL10502377 0.77 KMT2A (1.00) KMT2ATSHRALDH1A1HSD17B10KDM4E
SCHEMBL6791993 0.76 CYP1A2 (0.53) KMT2ATSHRCYP1A2CYP2D6CYP2C19
SCHEMBL22524980 0.76 KMT2A (0.50) KMT2ATSHRCYP1A2CYP2D6CYP2C19
SCHEMBL21765032 0.74 MAPT (0.69) KMT2ATSHRCYP1A2CYP2D6CYP2C19
SCHEMBL26617636 0.73 KMT2A (0.84) KMT2ATSHRALDH1A1HSD17B10KDM4E
SCHEMBL6415809 0.73 KMT2A (0.84) KMT2ATSHRALDH1A1HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
EP-1003712-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-31 EP disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed
WO-1999007669-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-18 WO disclosed