SCHEMBL8060454

SCHEMBL8060454

O=C(/C=C/c1ccccc1)Nc1ccc(Cl)cc1C(=O)O

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 6/20 0.75
TRPA1 O75762 3/20 0.73
TRPM2 O94759 2/20 0.62
MMP1 P03956 3/20 0.61
MMP2 P08253 3/20 0.61
MMP9 P14780 3/20 0.61
MAPT P10636 2/20 0.61
MAOA P21397 1/20 0.60
MAOB P27338 1/20 0.60
MEN1 O00255 2/20 0.60
NPC1 O15118 2/20 0.60
RAB9A P51151 2/20 0.60
KMT2A Q03164 2/20 0.60
SMN1; SMN2 Q16637 2/20 0.60
KDM4E B2RXH2 2/20 0.60
ALDH1A1 P00352 1/20 0.60
HPGD P15428 1/20 0.60
NPSR1 Q6W5P4 1/20 0.60
CYP1A2 P05177 1/20 0.60
CYP3A4 P08684 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8060457 1.00 EGFR (0.75) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL8065883 0.93 TRPA1 (0.75) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL8065880 0.93 TRPA1 (0.75) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL420925 0.92 TRPM2 (0.74) EGFRTRPA1TRPM2MAPTMEN1
SCHEMBL420926 0.92 TRPM2 (0.74) EGFRTRPA1TRPM2MAPTMEN1
SCHEMBL8059594 0.92 MEN1 (0.67) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL8059593 0.92 MEN1 (0.67) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL417074 0.90 EGFR (0.62) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL417073 0.90 EGFR (0.62) EGFRTRPA1TRPM2MMP1MMP2
SCHEMBL8060354 0.89 TRPA1 (0.73) EGFRTRPA1TRPM2MMP1MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed